Welcome and Introductions
Mark S. Frankel, PhD, Director, Program on Scientific Freedom, Responsibility and Law, AAAS, and Peter Agre, MD, President, AAAS and Director, Johns Hopkins Malaria Research Institute

Implementing Personalized Medicine
Chair: Peter Agre, MD, President, AAAS and Director, Johns Hopkins Malaria Research Institute
Speaker: Francis Collins, MD, PhD, Director of the National Institutes of Health [PowerPoint Presentation] [PDF]

Dr. Collins will discuss the scientific and translational challenges for implementing personalized medicine.

The FDA Perspective
Chair: James Kelly, JD, President and CEO, Food and Drug Law Institute (FDLI)
Speaker: Margaret A. Hamburg, MD, Commissioner of the U.S. Food and Drug Administration [PDF]

Commissioner Hamburg will discuss that agency's role in implementing personalized medicine.

Comparative Effectiveness Research and Personalized Medicine
Chair: Deborah Runkle, Senior Program Associate, AAAS
Speaker: Harold Sox, MD, Editor Emeritus, Annals of Internal Medicine, Adjunct Professor, Dartmouth Medical School [PowerPoint Presentation] [PDF]

Dr. Sox will discuss policy issues associated with comparative effectiveness research in the context of personalized medicine.

LUNCH (on your own)

Panel: Health IT and Personalized Medicine
Speakers will discuss the opportunities and challenges presented by health IT from a variety of perspectives.    

Chair: Michael Stebbins, PhD, Assistant Director for Biotechnology, Office of Science and Technology Policy, The White House

Policy Implications
Speaker: John Glaser, PhD, Senior Advisor, National Coordinator for Health Information Technology, U.S. Department of Health and Human Services [PowerPoint Presentation] [PDF]

Health IT as a Research Tool
Speaker: Rex Chisholm, PhD, Dean for Research, Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University [PowerPoint Presentation] [PDF]

Health IT and Personalized Medicine (Continued)

Health IT in Clinical Practice
Speaker: Linda Fischetti, RN, MS, Chief Health Informatics Officer, Veterans Health Administration, US Department of Veterans Affairs [PowerPoint Presentation] [PDF]

Legal and Ethical Considerations
Speaker: Mark A. Rothstein, JD, Herbert F. Boehl Chair of Law and Medicine, University of Louisville School of Medicine [PowerPoint Presentation] [PDF]

Adjourn

Continental Breakfast

Biomarkers and Clinical Care
Chair: Mark S. Frankel, PhD, Director, Program on Scientific Freedom, Responsibility and Law, AAAS
Speaker: Mark J. Ratain, MD, University of Chicago [PowerPoint Presentation] [PDF]

Dr. Ratain will discuss the status of discovery of molecular biomarkers that improve understanding of disease and individual differences.

Panel: Case Studies
Chair: Katrina L. Kelner, PhD, Editor, Science Translational Medicine, AAAS

Directing the Course of Treatment – development of drugs to treat disease subgroups (lung cancer)
Speaker: William Pao, MD, Assistant Director, Personalized Cancer Medicine, Vanderbilt University [PowerPoint Presentation] [PDF]

Getting the Dose Right (Plavix)
Speaker: Alan Shuldiner, MD, John L. Whitehurst Professor of Medicine, University of Maryland Medical Center [PowerPoint Presentation] [PDF]

Case Studies (Continued)

Avoiding Adverse Events (Abacavir)
Speaker: Hawazin Faruki, DrPH, Vice President, Clinical Development, Laboratory Corporation of America [PowerPoint Presentation] [PDF]

Lessons Learned from Case Studies
Speaker: Steven D. Averbuch, MD, Vice President, Oncology Transition Strategy & Development and Head, Pharmacodiagnostics, Global Clinical Research
Bristol-Myers Squibb Company [PowerPoint Presentation] [PDF]

Dr. Averbuch will discuss the obstacles ahead in the clinical application of biomarkers.

Audience/Panel Interaction: Making Difficult Choices
Using electronic audience-response technology, a panel will interact with the audience as together they try to decide how they would react to a difficult case. Panelists will represent the following perspectives:

Chair: Joseph G. Perpich, MD, Chair, AAAS Committee on Scientific Freedom and Responsibility and President, JG Perpich, LLC.

Physician: Nilofer Azad, MD, Assistant Professor, Gastrointestinal Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

Patient Advocate: Nancy Davenport-Ennis, Founder and CEO, National Patient Advocate Foundation

Closing Remarks
Mark S. Frankel, PhD, Director, Program on Scientific Freedom, Responsibility and Law, AAAS